Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W Locasale, Alexandra R Grassian, Tamar Melman, Costas A Lyssiotis, Katherine R Mattaini, Adam J Bass, Gregory Heffron, Christian M Metallo, Taru Muranen, Hadar Sharfi, Atsuo T Sasaki, Dimitrios Anastasiou, Edouard Mullarky, Natalie I Vokes, Mika Sasaki, Rameen Beroukhim, Gregory Stephanopoulos, Azra H Ligon, Matthew Meyerson, Andrea L Richardson, Lynda Chin, Gerhard Wagner, John M Asara, Joan S Brugge, Lewis C Cantley and Matthew G Vander Heiden
http://www.nature.com/ng/journal/v43/n9/full/ng.890.html

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels
W.-H. Tong, C. Sourbier, G. Kovtunovych, S.Y. Jeong, M. Vira, M. Ghosh, V.V. Romero, R. Sougrat, S. Vaulont, B. Viollet, Y.-S. Kim, S. Lee, J. Trepel, R. Srinivasan, G. Bratslavsky, Y. Yang, W.M. Linehan, and T.A. Rouault
http://www.cell.com/cancer-cell/abstract/S1535-6108%2811%2900268-6

E2F transcription factor-1 regulates oxidative metabolism
Emilie Blanchet, Jean-Sébastien Annicotte, Sylviane Lagarrigue, Victor Aguilar, Cyrielle Clapé, Carine Chavey, Vanessa Fritz, François Casas, Florence Apparailly, Johan Auwerx and Lluis Fajas
http://www.nature.com/ncb/journal/v13/n9/abs/ncb2309.html?lang=en

Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis
Michael A. Dengler, Annette M. Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak, Peter Scheurich, Matthias Schwab, Walter E. Aulitzky, Heiko van der Kuip
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025139

PPAR-delta Mediates a Ski-induced Shift from Glycolysis to Oxidative Energy Metabolism
Fang Ye, Helene Lemieux, Charles L. Hoppel, Richard W. Hanson, Parvin Hakimi, Colleen M. Croniger, Michelle Puchowicz, Vernon E. Anderson, Hisashi Fujioka, and Ed Stavnezer
http://www.jbc.org/cgi/content/abstract/M111.292029v1

Metabolic state of glioma stem cells and nontumorigenic cells
Erina Vlashi, Chann Lagadec, Laurent Vergnes, Tomoo Matsutani, Kenta Masui, Maria Poulou, Ruxandra Popescu, Lorenza Della Donna, Patrick Evers, Carmen Dekmezian, Karen Reue, Heather Christofk, Paul S. Mischel, and Frank Pajonk
http://www.pnas.org/content/108/38/16062.abstract?etoc

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
Cen Zhang, Meihua Lin, Rui Wu, Xiaowen Wang, Bo Yang, Arnold J. Levine, Wenwei Hu, and Zhaohui Feng
http://www.pnas.org/content/108/39/16259.abstract?etoc

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism
Anna N. Cvrljevic, David Akhavan, Min Wu, Paul Martinello, Frank B. Furnari, Amelia J. Johnston, Deliang Guo, Lisa Pike, Webster K. Cavenee, Andrew M. Scott, Paul S. Mischel, Nick J. Hoogenraad, and Terrance G. Johns
http://jcs.biologists.org/content/124/17/2938.abstract

PPAR  Mediates a Ski-induced Shift from Glycolysis to Oxidative Energy Metabolism
Fang Ye, Helene Lemieux, Charles L. Hoppel, Richard W. Hanson, Parvin Hakimi, Colleen M. Croniger, Michelle Puchowicz, Vernon E. Anderson, Hisashi Fujioka, and Ed Stavnezer
http://www.jbc.org/cgi/content/abstract/M111.292029v2

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Antimetabolites / starvation / ischemia
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2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma
Silvia Ramírez-Peinado, Fermín Alcázar-Limones, Laura Lagares-Tena, Nadia El Mjiyad, Alfredo Caro-Maldonado, Oscar M Tirado, and Cristina Muñoz-Pinedo
http://cancerres.aacrjournals.org/cgi/content/abstract/0008-5472.CAN-11-0759v1

Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy
Ryuji Yamaguchi, Edith Janssen, Guy Perkins, Mark Ellisman, Shinichi Kitada, John C. Reed
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024102

Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
Manuela Polimeni, Claudia Voena, Joanna Kopecka, Chiara Riganti, Gianpiero Pescarmona, Amalia Bosia and Dario Ghigo
http://www.biochemj.org/bj/439/bj4390141.htm

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated
[in yeast]
Lydia M. Castelli, Jennifer Lui, Susan G. Campbell, William Rowe, Leo A. H. Zeef, Leah E. A. Holmes, Nathaniel P. Hoyle, Jonathon Bone, Julian N. Selley, Paul F. G. Sims, and Mark P. Ashe
http://www.molbiolcell.org/content/22/18/3379.abstract?etoc

MondoA senses non-glucose sugars: regulation of TXNIP and the hexose transport curb
Carrie A. Stoltzman, Mohan R. Kaadige, Christopher W. Peterson, and Donald E. Ayer
http://www.jbc.org/cgi/content/abstract/M111.275503v1

Targeted killing of a mammalian cell based upon its specialized metabolic state
Peter B. Alexander, Jian Wang, and Steven L. McKnight
http://www.pnas.org/content/108/38/15828.abstract?etoc

Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy
Thomas Farkas, Mads Daugaard, and Marja Jaattela
http://www.jbc.org/cgi/content/abstract/M111.269134v1

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress
X Liu and G Hajnóczky
http://www.nature.com/cdd/journal/v18/n10/full/cdd201113a.html

Intracellular zinc release-activated ERK-dependent GSK-3β–p53 and Noxa–Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
C-L Lin, H-C Tseng, W-P Chen, M-J Su, K-M Fang, R-F Chen and M-L Wu
http://www.nature.com/cdd/journal/v18/n10/abs/cdd201180a.html

Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor
D Chauvier, S Renolleau, S Holifanjaniaina, S Ankri, M Bezault, L Schwendimann, C Rousset, R Casimir, J Hoebeke, M Smirnova, G Debret, A-P Trichet, Y Carlsson, X Wang, E Bernard, M Hébert, J-M Rauzier, S Matecki, A Lacampagne, P Rustin, J Mariani, H Hagberg, P Gressens, C Charriaut-Marlangue and E Jacotot
http://www.nature.com/cddis/journal/v2/n9/full/cddis201187a.html

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AMPK/mTOR
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Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer cells by a novel AMPK activator
Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, Hsiao-Ching Yang, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen
http://www.jbc.org/cgi/content/abstract/M111.264598v1

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism.
Maciver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG.
http://www.ncbi.nlm.nih.gov/pubmed/21930968

Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction
J.-Y. Lu, Y.-Y. Lin, J.-C. Sheu, J.-T. Wu, F.-J. Lee, Y. Chen, M.-I. Lin, F.-T. Chiang, T.-Y. Tai, S.L. Berger, Y. Zhao, K.-S. Tsai, H. Zhu, L.-M. Chuang, and J.D. Boeke
http://www.cell.com/abstract/S0092-8674%2811%2900888-9

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Y. Yang, D. Atasoy, H.H. Su, and S.M. Sternson
http://www.cell.com/abstract/S0092-8674%2811%2900882-8

Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors
T. De Raedt, Z. Walton, J.L. Yecies, D. Li, Y. Chen, C.F. Malone, O. Maertens, S.M. Jeong, R.T. Bronson, V. Lebleu, R. Kalluri, E. Normant, M.C. Haigis, B.D. Manning, K.-K. Wong, K.F. Macleod, and K. Cichowski
http://www.sciencedirect.com/science/article/pii/S1535610811003114

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
Beatrice T. Wang, Gregory S. Ducker, Andrea J. Barczak, Rebecca Barbeau, David J. Erle, and Kevan M. Shokat
http://www.pnas.org/content/108/37/15201.abstract?etoc

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer
Joanna C. Chan, Katherine M. Hannan, Kim Riddell, Pui Yee Ng, Abigail Peck, Rachel S. Lee, Sandy Hung, Megan V. Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E. Sheppard, Brian A. Hemmings, Michael N. Hall, Ricky W. Johnstone, Grant A. McArthur, Ross D. Hannan, Richard B. Pearson
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/188/ra56

Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and downregulation of p62/sequestosome 1
Shengbing Huang, Zhineng J. Yang, Chunrong Yu, and Frank A. Sinicrope
http://www.jbc.org/cgi/content/abstract/M111.297432v1

The Tumor Suppressive MicroRNA miR-218 Targets the mTOR Component Rictor and Inhibits AKT Phosphorylation in Oral Cancer
Atsushi Uesugi, Ken-ichi Kozaki, Tomohiko Tsuruta, Mayuko Furuta, Kei-ichi Morita, Issei Imoto, Ken Omura, and Johji Inazawa
http://cancerres.aacrjournals.org/cgi/content/abstract/71/17/5765

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Hypoxia
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Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
Christian Frezza, Liang Zheng, Daniel A. Tennant, Dmitri B. Papkovsky, Barbara A. Hedley, Gabriela Kalna, David G. Watson, Eyal Gottlieb
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0024411

HDAC4 regulates HIF1α lysine acetylation and cancer cell response to hypoxia
Hao Geng, Chris T. Harvey, Janet Pittsenbarger, Qiong Liu, Tomasz M. Beer, Changhui Xue, and David Z. Qian
http://www.jbc.org/cgi/content/abstract/M111.257055v1

Analysis of Hypoxia and Hypoxia-Like States through Metabolite Profiling
Julie E. Gleason, David J. Corrigan, James E. Cox, Amit R. Reddi, Lauren A. McGinnis, Valeria C. Culotta
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0024741

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong, Daniele M. Gilkes, Huafeng Zhang, Jasper Chen, Hong Wei, Pallavi Chaturvedi, Stephanie I. Fraley, Chun-Ming Wong, Ui-Soon Khoo, Irene Oi-Lin Ng, Denis Wirtz, and Gregg L. Semenza
http://www.pnas.org/content/108/39/16369.abstract?etoc

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression
Muhammad Zaeem Noman, Bassam Janji, Bozena Kaminska, Kris Van Moer, Sandrine Pierson, Piotr Przanowski, Stéphanie Buart, Guy Berchem, Pedro Romero, Fathia Mami-Chouaib, and Salem Chouaib
http://cancerres.aacrjournals.org/cgi/content/abstract/71/18/5976

Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer
Kasper Toustrup, Brita Singers Sørensen, Marianne Nordsmark, Morten Busk, Carsten Wiuf, Jan Alsner, and Jens Overgaard
http://cancerres.aacrjournals.org/cgi/content/abstract/71/17/5923

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Reviews / Comments
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Targeting cancer metabolism: a therapeutic window opens
Matthew G. Vander Heiden
http://www.nature.com/nrd/journal/v10/n9/full/nrd3504.html

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Maria M. Mihaylova and Reuben J. Shaw
http://www.nature.com/ncb/journal/v13/n9/abs/ncb2329.html

AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
D. Grahame Hardie
http://genesdev.cshlp.org/cgi/content/abstract/25/18/1895

AMP-activated protein kinase: also regulated by ADP?
D. Grahame Hardie, David Carling, Steven J. Gamblin
http://www.sciencedirect.com/science/article/pii/S0968000411000958

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
A Lemarie and S Grimm
http://www.nature.com/onc/journal/v30/n38/full/onc2011167a.html

ERK to Conserve Resources
Annalisa M. VanHook
ERK7 suppresses protein secretion in response to amino acid starvation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/192/ec271

Cell death: Linking metabolism to apoptotic sensitivity
BCL-XL suppresses acetyl CoA production to protect cells against apoptosis.
http://www.nature.com/nrm/journal/v12/n10/full/nrm3195.html

Removing a Metabolic Roadblock
Annalisa M. VanHook
ERK signaling alters flux through the tricarboxylic acid cycle to influence cell proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/188/ec240

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer ▶
Richard Possemato, Kevin M. Marks, Yoav D. Shaul, Michael E. Pacold, Dohoon Kim, Kıvanç Birsoy, Shalini Sethumadhavan, Hin-Koon Woo, Hyun G. Jang, Abhishek K. Jha, Walter W. Chen, Francesca G. Barrett, Nicolas Stransky, Zhi-Yang Tsun, Glenn S. Cowley, Jordi Barretina, Nada Y. Kalaany, Peggy P. Hsu, Kathleen Ottina, Albert M. Chan, Bingbing Yuan, Levi A. Garraway, David E. Root, Mari Mino-Kenudson, Elena F. Brachtel, Edward M. Driggers & David M. Sabatini
http://www.nature.com/nature/journal/v476/n7360/full/nature10350.html

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase ▶
Christian Frezza, Liang Zheng, Ori Folger, Kartik N. Rajagopalan, Elaine D. MacKenzie, Livnat Jerby, Massimo Micaroni, Barbara Chaneton, Julie Adam, Ann Hedley, Gabriela Kalna, Ian P. M. Tomlinson, Patrick J. Pollard, Dave G. Watson, Ralph J. Deberardinis, Tomer Shlomi, Eytan Ruppin & Eyal Gottlieb
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10363.html

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
Alexandra R. Grassian, Christian M. Metallo, Jonathan L. Coloff, Gregory Stephanopoulos, and Joan S. Brugge
http://genesdev.cshlp.org/cgi/content/abstract/25/16/1716

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF-B
Renée F. Johnson, Ini-Isabée Witzel, and Neil D. Perkins
http://cancerres.aacrjournals.org/cgi/content/abstract/71/16/5588

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer
Joanna Zawacka-Pankau, Vera V. Grinkevich, Sabine Hunten, Fedor Nikulenkov, Angela Gluch, Hai Li, Martin Enge, Alexander Kel, and Galina Selivanova
http://www.jbc.org/cgi/content/abstract/M111.240812v1

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo
Christian D. Young, Andrew S. Lewis, Michael C. Rudolph, Marisa D. Ruehle, Matthew R. Jackman, Ui J. Yun, Olesya Ilkun, Renata Pereira, E. Dale Abel, Steven M. Anderson
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023205

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Cell metabolism
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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
T.R. Peterson, S.S. Sengupta, T.E. Harris, A.E. Carmack, S.A. Kang, E. Balderas, D.A. Guertin, K.L. Madden, A.E. Carpenter, B.N. Finck, and D.M. Sabatini
http://www.cell.com/abstract/S0092-8674%2811%2900709-4

Regulation of TFEB and V-ATPases by mTORC1
Samuel Peña-Llopis, Silvia Vega-Rubin-de-Celis, Jacob C Schwartz, Nicholas C Wolff, Tram Anh T Tran, Lihua Zou, Xian-Jin Xie, David R Corey and James Brugarolas
http://www.nature.com/emboj/journal/v30/n16/full/emboj2011257a.html

ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
Houkai Li, Qingshu Meng, Fei Xiao, Shanghai Chen, Ying Du, Junjie Yu, Chunxia Wang and Feifan Guo
http://www.biochemj.org/bj/438/bj4380283.htm

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
C.H. Yi, H. Pan, J. Seebacher, I.-H. Jang, S.G. Hyberts, G.J. Heffron, M.G. Vander Heiden, R. Yang, F. Li, J.W. Locasale, H. Sharfi, B. Zhai, R. Rodriguez-Mias, H. Luithardt, L.C. Cantley, G.Q. Daley, J.M. Asara, S.P. Gygi, G. Wagner, C.-F. Liu, and J. Yuan
http://dx.doi.org/10.1016/j.cell.2011.06.050

Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
Rui Gong, Li Li, Yi Liu, Ping Wang, Huirong Yang, Ling Wang, Jingdong Cheng, Kun-Liang Guan, and Yanhui Xu
http://genesdev.cshlp.org/cgi/content/abstract/25/16/1668

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Metabolism-targeting drugs, starvation
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Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
D. A. Chan, P. D. Sutphin, P. Nguyen, S. Turcotte, E. W. Lai, A. Banh, G. E. Reynolds, J.-T. Chi, J. Wu, D. E. Solow-Cordero, M. Bonnet, J. U. Flanagan, D. M. Bouley, E. E. Graves, W. A. Denny, M. P. Hay, A. J. Giaccia
http://stm.sciencemag.org/content/3/94/94ra70

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
J Huelsenbeck, C Henninger, A Schad, K J Lackner, B Kaina and G Fritz
http://www.nature.com/cddis/journal/v2/n8/full/cddis201165a.html

The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53- Independent Manner in Colon and Breast Cancer Cells
María Angel García, Esther Carrasco, Margarita Aguilera, Pablo Alvarez, Carmen Rivas, Joaquin María Campos, Jose Carlos Prados, Miguel Angel Calleja, Mariano Esteban, Juan Antonio Marchal, Antonia Aránega
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023887

Auto-activation of cJUN by amino acid deprivation of hepatocellular carcinoma cells reveals a novel cJUN-mediated signaling pathway
Lingchen Fu, Mukundh Balasubramanian, Jixiu Shan, Elizabeth Dudenhausen, and Michael S. Kilberg
http://www.jbc.org/cgi/content/abstract/M111.277673v1

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Hypoxia / ischemia / oxidative stress
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Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
Galina A. Gusarova, Humberto E. Trejo, Laura A. Dada, Arturo Briva, Lynn C. Welch, Robert B. Hamanaka, Gökhan M. Mutlu, Navdeep S. Chandel, Murali Prakriya, and Jacob I. Sznajder
http://mcb.asm.org/cgi/content/abstract/31/17/3546

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
Paul T. Mungai, Gregory B. Waypa, Amit Jairaman, Murali Prakriya, Danijela Dokic, Molly K. Ball, and Paul T. Schumacker
http://mcb.asm.org/cgi/content/abstract/31/17/3531

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment
Alvaro Avivar-Valderas, Eduardo Salas, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Chandandeep Nagi, Jayanta Debnath, and Julio A. Aguirre-Ghiso
http://mcb.asm.org/cgi/content/abstract/31/17/3616

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death
Xi Feng, Xing Liu, Wei Zhang and Wuhan Xiao
http://www.nature.com/emboj/journal/v30/n16/full/emboj2011248a.html

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia
M Neubert, D A Ridder, P Bargiotas, S Akira and M Schwaninger
http://www.nature.com/cdd/journal/v18/n9/full/cdd201129a.html

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Reviews / comments
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The Logic Linking Protein Acetylation and Metabolism
L. Guarente
http://www.sciencedirect.com/science/article/pii/S1550413111002695

From the urea cycle to autophagy: Alfred J. Meijer
Daniel J. Klionsky and Alfred J. Meijer
http://www.landesbioscience.com/journals/autophagy/article/15192/

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
Libin Shang and Xiaodong Wang
http://www.landesbioscience.com/journals/autophagy/article/15860/

Regulation of autophagy by lysosomal positioning
Viktor I. Korolchuk and David C. Rubinsztein
http://www.landesbioscience.com/journals/autophagy/article/15862/

Death by Acetylation
Nancy R. Gough
Reduction in acetyl-CoA and protein N-acetylation is one mechanism by which Bcl-xL exerts its antiapoptotic effect.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/187/ec231

Metabolism: Flexible flux
Using unbiased functional genomics and metabolomics methods, two groups have demonstrated the importance of the serine synthesis pathway for tumorigenesis.
http://www.nature.com/nrc/journal/v11/n9/full/nrc3128.html

Metabolic regulation by ERK
A novel role for ERK signalling in the regulation of PDH flux
http://www.nature.com/nrm/journal/v12/n9/full/nrm3179.html

Meeting the (N-Terminal) End with Acetylation
J.L. Andersen and S. Kornbluth
http://dx.doi.org/10.1016/j.cell.2011.07.024

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13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression
S. Hu, A. Balakrishnan, R.A. Bok, B. Anderton, P.E.Z. Larson, S.J. Nelson, J. Kurhanewicz, D.B. Vigneron, and A. Goga
http://www.sciencedirect.com/science/article/pii/S1550413111002130

The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
Claire L. Green, Catherine M. Evans, Lu Zhao, Robert K. Hills, Alan K. Burnett, David C. Linch, and Rosemary E. Gale
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/2/409

Glucose, Not Glutamine, Is the Dominant Energy Source Required for Proliferation and Survival of Head and Neck Squamous Carcinoma Cells
Sandulache, VC; Ow, TJ; Pickering, CR; Frederick, MJ; Zhou, G; Fokt, I; Davis-Malesevich, M; Priebe, W; Myers, JN
http://onlinelibrary.wiley.com/doi/10.1002/cncr.25868/abstract

Energy Metabolism in H460 Lung Cancer Cells: Effects of Histone Deacetylase Inhibitors
Nívea Dias Amoêdo, Mariana Figueiredo Rodrigues, Paula Pezzuto, Antonio Galina, Rodrigo Madeiro da Costa, Fábio Ceneviva Lacerda de Almeida, Tatiana El-Bacha, Franklin David Rumjanek
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022264

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
Andrey Parkhitko, Faina Myachina, Tasha A. Morrison, Khadijah M. Hindi, Neil Auricchio, Magdalena Karbowniczek, J. Julia Wu, Toren Finkel, David J. Kwiatkowski, Jane J. Yu, and Elizabeth Petri Henske
http://www.pnas.org/content/108/30/12455.abstract?etoc

Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis
Yunfei Zhou, Yan Zhou, Takashi Shingu, Li Feng, Zhao Chen, Marcia Ogasawara, Michael J. Keating, Seiji Kondo, and Peng Huang
http://www.jbc.org/cgi/content/abstract/M111.260935v1

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Cell metabolism
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HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi, Ruoning Wang, Gonghua Huang, Peter Vogel, Geoffrey Neale, Douglas R. Green, and Hongbo Chi
HIF1α induction by mTOR represents a metabolic checkpoint for the differentiation of TH17 and Treg cells.
http://jem.rupress.org/cgi/content/abstract/208/7/1367?etoc

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
J.L. Yecies, H.H. Zhang, S. Menon, S. Liu, D. Yecies, A.I. Lipovsky, C. Gorgun, D.J. Kwiatkowski, G.S. Hotamisligil, C.-H. Lee, and B.D. Manning
http://linkinghub.elsevier.com/retrieve/pii/S1550-4131(11)00220-8

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Starvation
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A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation
Victor W. Ho, Kelvin Leung, Anderson Hsu, Beryl Luk, June Lai, Sung Yuan Shen, Andrew I. Minchinton, Dawn Waterhouse, Marcel B. Bally, Wendy Lin, Brad H. Nelson, Laura M. Sly, and Gerald Krystal
http://cancerres.aacrjournals.org/cgi/content/abstract/71/13/4484

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
Heesun Cheong, Tullia Lindsten, Junmin Wu, Chao Lu, and Craig B. Thompson
http://www.pnas.org/content/108/27/11121.full

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Metabolic inhibitors
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Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
Yuhua Zhao, Hao Liu, Zixing Liu, Yan Ding, Susan P. LeDoux, Glenn L. Wilson, Richard Voellmy, Yifeng Lin, Wensheng Lin, Rita Nahta, Bolin Liu, Oystein Fodstad, Jieqing Chen, Yun Wu, Janet E. Price, and Ming Tan
http://cancerres.aacrjournals.org/cgi/content/abstract/71/13/4585

Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
Giuseppe Filomeni, Simone Cardaci, Ana Maria Da Costa Ferreira, Giuseppe Rotilio and Maria Rosa Ciriolo
http://www.biochemj.org/bj/437/bj4370443.htm

Poly(ADP-Ribose) Polymerase Inhibition Synergizes with 5-Fluorodeoxyuridine but not 5-Fluorouracil in Ovarian Cancer Cells
Amelia M. Huehls, Jill M. Wagner, Catherine J. Huntoon, Liyi Geng, Charles Erlichman, Anand G. Patel, Scott H. Kaufmann, and Larry M. Karnitz
http://cancerres.aacrjournals.org/cgi/content/abstract/71/14/4944

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.
Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J.
http://www.nature.com/nrurol/journal/v8/n3/full/nrurol.2010.234.html

NF- B mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase
Colleen R. M. Lemmon, Ju-Hyung Woo, Ellen Tully, Kathleen Wilsbach, and Edward Gabrielson
http://www.jbc.org/cgi/content/abstract/M111.274308v1

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
Isaam Ben Sahra, Claire Regazzetti, Guillaume Robert, Kathiane Laurent, Yannick Le Marchand-Brustel, Patrick Auberger, Jean-François Tanti, Sophie Giorgetti-Peraldi, and Frédéric Bost
http://cancerres.aacrjournals.org/cgi/content/abstract/71/13/4366

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AMPK/mTOR
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Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
Antje S. Löffler, Sebastian Alers, Alexandra M. Dieterle, Hildegard Keppeler, Mirita Franz-Wachtel, Mondira Kundu, David G. Campbell, Sebastian Wesselborg, Dario R. Alessi and Björn Stork
http://www.landesbioscience.com/journals/autophagy/article/15451/

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
Elaine A. Dunlop, David K. Hunt, Hugo A. Acosta-Jaquez, Diane C. Fingar and Andrew R. Tee
http://www.landesbioscience.com/journals/autophagy/article/15491/

REDOX REGULATES mTORC1 ACTIVITY BY MODULATING THE TSC1/TSC2-Rheb PATHWAY
Sei Yoshida, Sungki Hong, Tsukasa Suzuki, Shigeyuki Nada, Aristotle Mannar Mannan, Junying Wang, Masato Okada, Kun-Liang Guan, and Ken Inoki
http://www.jbc.org/cgi/content/abstract/M111.238014v1

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Hypoxia / ischemia
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Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
Patrick A. Mayes, Nathan G. Dolloff, Colin J. Daniel, J. Judy Liu, Lori S. Hart, Kageaki Kuribayashi, Joshua E. Allen, David I.H. Jee, Jay F. Dorsey, Yingqiu Y. Liu, David T. Dicker, J. Martin Brown, Emma E. Furth, Peter S. Klein, Rosalie C. Sears, and Wafik S. El-Deiry
http://cancerres.aacrjournals.org/cgi/content/abstract/71/15/5265

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
E L Bell, B M Emerling, S J H Ricoult and L Guarente
http://www.nature.com/onc/journal/v30/n26/abs/onc201137a.html?WT.ec_id=ONC-201106

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice
Hai-Ying Shen, Theresa A Lusardi, Rebecca L Williams-Karnesky, Jing-Quan Lan, David J Poulsen and Detlev Boison
http://www.nature.com/jcbfm/journal/v31/n7/full/jcbfm201130a.html?WT.ec_id=JCBFM-201107

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells ▶
Andrea Facciabene, Xiaohui Peng, Ian S. Hagemann, Klara Balint, Andrea Barchetti et al.
http://www.nature.com/nature/journal/v475/n7355/full/nature10169.html

Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc expression after hypoxic stress
Sudha Talwar, Junfei Jin, Brittany Carroll, Angen Liu, Boyd Marion Gillespie, and Viswanathan Palanisamy
http://www.jbc.org/cgi/content/abstract/M111.255927v1

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia
Chad Siegel, Jun Li, Fudong Liu, Sharon E. Benashski, and Louise D. McCullough
http://www.pnas.org/content/108/28/11662.abstract?etoc

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
Angelika S. Rambold, Brenda Kostelecky, Natalie Elia, and Jennifer Lippincott-Schwartz
http://www.pnas.org/content/108/25/10190.abstract?etoc

Mitochondria regulate autophagy by conserved signalling pathways
Martin Graef and Jodi Nunnari
http://www.nature.com/emboj/journal/v30/n11/full/emboj2011104a.html

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
J. S. Oakhill et al.
The cellular energy sensor adenosine monophosphate–activated protein kinase also binds and is regulated by adenosine diphosphate.
http://www.sciencemag.org/cgi/content/abstract/332/6036/1433

Phospholipase D mediates nutrient input to mTORC1
Limei Xu, Darin Salloum, Phil S. Medlin, Mahesh Saqcena, Paige Yellen, Benjamin Perrella, and David A Foster
http://www.jbc.org/cgi/content/abstract/M111.249631v2

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Cancer metabolism
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Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
L. Lv, D. Li, D. Zhao, R. Lin, Y. Chu, H. Zhang, Z. Zha, Y. Liu, Z. Li, Y. Xu, G. Wang, Y. Huang, Y. Xiong, K.-L. Guan, and Q.-Y. Lei
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900371-6

Mitochondrial Dysfunction in Cancer Cells Due to Aberrant Mitochondrial Replication
Yuriy Shapovalov, David Hoffman, Daniel Zuch, Karen L. de Mesy Bentley, and Roman A. Eliseev
http://www.jbc.org/content/286/25/22331.abstract?sid=1372cbd0-db93-4f43-b9a7-6ed7962bb639

Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization
Giorgia Nardo, Elena Favaro, Matteo Curtarello, Lidia Moserle, Elisabetta Zulato, Luca Persano, Elisabetta Rossi, Giovanni Esposito, Marika Crescenzi, Oriol Casanovas, Ulrike Sattler, Wolfgang Mueller-Klieser, Barbara Biesalski, Oliver Thews, Rossella Canese, Egidio Iorio, Paola Zanovello, Alberto Amadori, and Stefano Indraccolo
http://cancerres.aacrjournals.org/cgi/content/abstract/71/12/4214

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Hypoxia
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A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2
S. Choksi, Y. Lin, Y. Pobezinskaya, L. Chen, C. Park, M. Morgan, T. Li, S. Jitkaew, X. Cao, Y.-S. Kim, H.-S. Kim, P. Levitt, G. Shih, M. Birre, C.-X. Deng, and Z.-g. Liu
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900335-2

HIF-1α Mediates Tumor Hypoxia to Confer a Perpetual Mesenchymal Phenotype for Malignant Progression
Young-Gun Yoo, Jared Christensen, Jie Gu, L. Eric Huang
Hypoxia-induced genetic alterations induce epithelial-mesenchymal transition and tumor progression.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/178/pt4?etoc

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Ischemia
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Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
Shaida A Andrabi, Ho Chul Kang, Jean-Francois Haince, Yun-Il Lee, Jian Zhang, Zhikai Chi, Andrew B West, Raymond C Koehler, Guy G Poirier, Ted M Dawson and Valina L Dawson
http://www.nature.com/nm/journal/v17/n6/full/nm.2387.html

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
Chengqun Huang, Allen M. Andres, Eric P. Ratliff, Genaro Hernandez, Pamela Lee, Roberta A. Gottlieb
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020975

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Autophagy
———————-

TFEB Links Autophagy to Lysosomal Biogenesis
C. Settembre et al.
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.
http://www.sciencemag.org/cgi/content/abstract/332/6036/1429

Relieving Autophagy and 4EBP1 from Rapamycin Resistance
Beat Nyfeler, Philip Bergman, Ellen Triantafellow, Christopher J. Wilson, Yanyi Zhu, Branko Radetich, Peter M. Finan, Daniel J. Klionsky, and Leon O. Murphy
http://mcb.asm.org/cgi/content/abstract/31/14/2867

Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy
Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils, Nathan R Brady
http://www.biomedcentral.com/1741-7007/9/38

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Reviews
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Biochimica et Biophysica Acta (BBA) – Molecular Cell Research
Volume 1813, Issue 7,  Pages 1261-1394 (July 2011)
Mitochondria and Cardioprotection
Edited by F. Di Lisa, E. Murphy and R. Schulz
http://www.sciencedirect.com/science/journal/01674889

Including:
- Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
Gregg L. Semenza
http://www.sciencedirect.com/science/article/pii/S0167488910002223
- Targeting fatty acid and carbohydrate oxidation – A novel therapeutic intervention in the ischemic and failing heart
Jagdip S. Jaswal, Wendy Keung, Wei Wang, John R. Ussher, Gary D. Lopaschuk
http://www.sciencedirect.com/science/article/pii/S0167488911000231

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion
Gabriel Loor, Jyothisri Kondapalli, Hirotaro Iwase, Navdeep S. Chandel, Gregory B. Waypa, Robert D. Guzy, Terry L. Vanden Hoek, Paul T. Schumacker
http://www.sciencedirect.com/science/article/pii/S0167488910003186

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News and views
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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
Dan Egan, Joungmok Kim, Reuben J. Shaw and Kun-Liang Guan
http://www.landesbioscience.com/journals/autophagy/article/15123/

Mitochondria breathe for autophagy
Koji Okamoto
http://www.nature.com/emboj/journal/v30/n11/full/emboj2011149a.html

Mitochondrial Dynamics: A Strategy for Avoiding Autophagy
L. Galluzzi, O. Kepp, and G. Kroemer
http://www.sciencedirect.com/science/article/pii/S096098221100529X

ATIA: A Link between Inflammation and Hypoxia
A. Lin
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900390-X

Shifting the Metabolic Program
Elizabeth M. Adler
Pyruvate kinase M2 interacts directly with hypoxia-inducible factor 1 to promote glycolytic metabolism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/176/ec157?etoc

Cancer metabolism: Feed it forward
Semenza and colleagues identify a positive feedback loop between the pyruvate kinase PKM2 and HIF1 that may explain how PKM2 can promote metabolic reprogramming of cancer cells.
http://www.nature.com/nrc/journal/v11/n7/full/nrc3094.html?WT.ec_id=NRC-201108

Ramping Up AMPK
L. Bryan Ray
The cellular energy sensor adenosine monophosphate–activated protein kinase also binds and is regulated by adenosine diphosphate.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/178/ec174?etoc

ADaPting to Energetic Stress
M. L. Bland and M. J. Birnbaum
What is the true activator of a key enzyme that controls cell energetics?
http://www.sciencemag.org/cgi/content/summary/332/6036/1387

Coordinating Autophagy and Lysosome Regulation
Stella M. Hurtley
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/178/ec175?etoc

Autophagy’s Top Chef
Ana Maria Cuervo
The transcription factor EB both controls lysosome formation and increases autophagy in cells experiencing starvation.
http://www.sciencemag.org/cgi/content/summary/332/6036/1392

Acetylation for Autophagy
Wei Wong
Acetylation of pyruvate kinase M2 inhibits its activity and triggers its autophagic degradation, leading to increased tumor cell proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/179/ec182?etoc

PKM2 and the Tricky Balance of Growth and Energy in Cancer
A.N. Macintyre and J.C. Rathmell
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900416-3
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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Ligia C. Gomes, Giulietta Di Benedetto and Luca Scorrano
http://www.nature.com/ncb/journal/v13/n5/abs/ncb2220.html?lang=en

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
Kathrin Zaugg, Yi Yao, Patrick T. Reilly, Karuppiah Kannan, Reza Kiarash, Jacqueline Mason, Ping Huang, Suzanne K. Sawyer, Benjamin Fuerth, Brandon Faubert, Tuula Kalliomäki, Andrew Elia, Xunyi Luo, Vincent Nadeem, David Bungard, Sireesha Yalavarthi, Joseph D. Growney, Andrew Wakeham, Yasmin Moolani, Jennifer Silvester, Annick You Ten, Walbert Bakker, Katsuya Tsuchihara, Shelley L. Berger, Richard P. Hill, Russell G. Jones, Ming Tsao, Murray O. Robinson, Craig B. Thompson, Guohua Pan, and Tak W. Mak
http://genesdev.cshlp.org/cgi/content/abstract/25/10/1041

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo
J.-H. Sheen, R. Zoncu, D. Kim, and D.M. Sabatini
http://www.cell.com/cancer-cell/abstract/S1535-6108%2811%2900122-X

Glucose deprivation is associated with Chk1 degradation through the ubiquitin–proteasome pathway and effective checkpoint response to replication blocks
Ae Jeong Kim, Hyun-Ju Kim, Hye Jin Jee, Naree Song, Minjee Kim, Yoe-Sik Bae, Jay H. Chung, Jeanho Yun
http://dx.doi.org/10.1016/j.bbamcr.2011.03.012

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation
Yueguang Rong, Christina McPhee, Shuangshen Deng, Lei Huang, Lilian Chen, Mei Liu, Kirsten Tracy, Eric H. Baehreck, Li Yu, and Michael J. Lenardo
http://www.pnas.org/content/108/19/7826.abstract?etoc

2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.
Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X, Savaraj N, Lampidis TJ.
http://www.springerlink.com/content/92272u108204m035/

IFI16 Induction by Glucose Restriction in Human Fibroblasts Contributes to Autophagy through Activation of the ATM/AMPK/p53 Pathway
Xin Duan, Larissa Ponomareva, Sudhakar Veeranki, Divaker Choubey
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019532

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Cancer metabolism
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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
Tzuling Cheng, Jessica Sudderth, Chendong Yang, Andrew R. Mullen, Eunsook S. Jin, José M. Matés, and Ralph J. DeBerardinis
http://www.pnas.org/content/108/21/8674.abstract?etoc

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
W. Luo, H. Hu, R. Chang, J. Zhong, M. Knabel, R. O’Meally, R.N. Cole, A. Pandey, and G.L. Semenza
http://www.cell.com/abstract/S0092-8674%2811%2900436-3

Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism
Andreja Šmerc, Eva Sodja, Matic Legiša
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019645

Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
Gregor Beuster, Kim Zarse, Christoph Kaleta, Rene Thierbach, Michael Kiehntopf, Pablo Steinberg, Stefan Schuster, and Michael Ristow
J. Biol. Chem. published 3 May 2011, 10.1074/jbc.M110.205229
http://www.jbc.org/cgi/content/abstract/M110.205229v1

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
L. Cai, B.M. Sutter, B. Li, and B.P. Tu
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900332-7

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Ischemia
—————-

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
N Badiola, C Penas, A Miñano-Molina, B Barneda-Zahonero, R Fadó, G Sánchez-Opazo, J X Comella, J Sabriá, C Zhu, K Blomgren, C Casas and J Rodríguez-Alvarez
http://www.nature.com/cddis/journal/v2/n4/abs/cddis201131a.html

RTEF-1, an upstream gene of HIF-1α, accelerates recovery from Ischemia
Yi Jin, Jiaping Wu, Xiaoxiao Song, Qinhui Song, Brittany L. Cully, Angela Messmer-Blust, Ming Xu, Shi-Yin Foo, Anthony Rosenzweig, and Jian Li
http://www.jbc.org/cgi/content/abstract/M111.237024v1

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia
Philippe Pasdois, Joanne E. Parker, Elinor J. Griffiths and Andrew P. Halestrap
http://www.biochemj.org/bj/436/bj4360493.htm

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Hypoxia
————–

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
B Kucejova, N E Sunny, A D Nguyen, R Hallac, X Fu, S Peña-Llopis, R P Mason, R J DeBerardinis, X-J Xie, R DeBose-Boyd, V D Kodibagkar, S C Burgess and J Brugarolas
http://www.nature.com/onc/journal/v30/n18/full/onc2010587a.html

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue
Sergio Rey, Weibo Luo, Larissa A. Shimoda, and Gregg L. Semenza
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/117/18/4988

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia
Fanny Bouquet, Marielle Ousset, Denis Biard, Frédérique Fallone, Stéphanie Dauvillier, Philippe Frit, Bernard Salles, and Catherine Muller
http://jcs.biologists.org/cgi/content/abstract/124/11/1943

Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells
D Trisciuoglio, C Gabellini, M Desideri, Y Ragazzoni, T De Luca, E Ziparo and D Del Bufalo
http://www.nature.com/cdd/journal/v18/n6/full/cdd2010175a.html

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Reviews
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Autophagy in the Cellular Energetic Balance
R. Singh and A.M. Cuervo
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2811%2900147-1

Reciprocal influence of the p53 and the hypoxic pathways
A Sermeus and C Michiels
http://www.nature.com/cddis/journal/v2/n5/full/cddis201148a.html

Targeting hypoxia in cancer therapy
William R. Wilson & Michael P. Hay
http://www.nature.com/nrc/journal/v11/n6/abs/nrc3064.html?lang=en

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
W van Veelen, S E Korsse, L van de Laar and M P Peppelenbosch
http://www.nature.com/onc/journal/v30/n20/abs/onc2010630a.html

Special issue:
Bioenergetics of Cancer – Edited by Rodrigue Rossignol
Biochimica et Biophysica Acta (BBA) – Bioenergetics
http://www.sciencedirect.com/science/issue/4898-2011-981929993-3159738

• Oxidative phosphorylation in cancer cells
Giancarlo Solaini, Gianluca Sgarbi, Alessandra Baracca
• Post-transcriptional regulation of the mitochondrial H+-ATP synthase: A key regulator of the metabolic phenotype in cancer
Imke M. Willers, José M. Cuezva
• Choosing between glycolysis and oxidative phosphorylation: A tumor’s dilemma?
Caroline Jose, Nadège Bellance, Rodrigue Rossignol
• Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism
Arnaud Chevrollier, Dominique Loiseau, Pascal Reynier, Georges Stepien
• The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
Rodrigo Diaz-Ruiz, Michel Rigoulet, Anne Devin
• Metabolic management of brain cancer
Thomas N. Seyfried, Michael A. Kiebish, Jeremy Marsh, Laura M. Shelton, Leanne C. Huysentruyt, Purna Mukherjee
• Mitochondrial proteases and cancer
Anne-Laure Bulteau, Aurelien Bayot
• Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment
Gabriel Arismendi-Morillo
• Genetic insights into OXPHOS defect and its role in cancer
Dhyan Chandra, Keshav K. Singh
• Learning from oncocytic tumors: Why choose inefficient mitochondria?
Giuseppe Gasparre, Giovanni Romeo, Michela Rugolo, Anna Maria Porcelli
• Metabolomics for mitochondrial and cancer studies
Deepak Nagrath, Christine Caneba, Thasni Karedath, Nadege Bellance
• Role of obesity-associated dysfunctional adipose tissue in cancer: A molecular nutrition approach
Pedro L. Prieto-Hontoria, Patricia Pérez-Matute, Marta Fernández-Galilea, Matilde Bustos, J. Alfredo Martínez, María J. Moreno-Aliaga
• Approaches for targeting mitochondria in cancer therapy
Gerard G.M. D’Souza, Mayura A Wagle, Vaibhav Saxena, Anee Shah
• Bioactive food components, cancer cell growth limitation and reversal of glycolytic metabolism   Review Article
Jaap Keijer, Melissa Bekkenkamp-Grovenstein, Dini Venema, Yvonne E.M. Dommels
• Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
Inthrani R. Indran, Grégory Tufo, Shazib Pervaiz, Catherine Brenner

———————–
News and views
———————–

Autophagy: Shaping the fate of mitochondria
http://www.nature.com/nrm/journal/v12/n6/full/nrm3116.html

Mitochondria unite to survive
Craig Blackstone and Chuang-Rung Chang
http://www.nature.com/ncb/journal/v13/n5/full/ncb0511-521.html

PK-M2 Makes Cells Sweeter on HIF1
D.A. Tennant
http://www.cell.com/abstract/S0092-8674%2811%2900535-6
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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
Min Zheng, Yan-Hai Wang, Xiao-Nan Wu, Su-Qin Wu, Bao-Ju Lu, Meng-Qiu Dong, Hongbing Zhang, Peiqing Sun, Sheng-Cai Lin, Kun-Liang Guan and Jiahuai Han
http://www.nature.com/ncb/journal/v13/n3/full/ncb2168.html

Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation
Yoo JinJoo, Jin-Ha Kim, Un-Beom Kang, Myeong-Hee Yu and Joon Kim
http://www.nature.com/emboj/journal/v30/n5/abs/emboj2010332a.html

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish
Yme U. van der Velden, Liqin Wang, John Zevenhoven, Ellen van Rooijen, Maarten van Lohuizen, Rachel H. Giles, Hans Clevers, and Anna-Pavlina G. Haramis
http://www.pnas.org/content/108/11/4358.abstract?etoc

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction
Sho W. Suzuki, Jun Onodera, Yoshinori Ohsumi
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017412

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
Libin Shang, She Chen, Fenghe Du, Shen Li, Liping Zhao, and Xiaodong Wang
http://www.pnas.org/content/108/12/4788.abstract?etoc

Implication of Snail in Metabolic Stress-Induced Necrosis
Cho Hee Kim, Hyun Min Jeon, Su Yeon Lee, Min Kyung Ju, Ji Young Moon, Hye Gyeong Park, Mi-Ae Yoo, Byung Tae Choi, Jong In Yook, Sung-Chul Lim, Song Iy Han, Ho Sung Kang
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018000

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
Qilong Wang, Bin Liang, Najeeb A. Shirwany, Ming-Hui Zou
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017234

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
C Algire, L Amrein, M Bazile, S David, M Zakikhani and M Pollak
http://www.nature.com/onc/journal/v30/n10/abs/onc2010483a.html

————–
Ischemia
————–

EndoG Links Bnip3-Induced Mitochondrial Damage and Caspase-Independent DNA Fragmentation in Ischemic Cardiomyocytes
Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A. Cook, Joan X. Comella, Daniel Sanchis
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017998

The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke
Jose C. Gomez-Sanchez, Maria Delgado-Esteban, Irene Rodriguez-Hernandez, Tomas Sobrino, Natalia Perez de la Ossa, Silvia Reverte, Juan P. Bolaños, Rogelio Gonzalez-Sarmiento, Jose Castillo, and Angeles Almeida
http://jem.rupress.org/cgi/content/abstract/208/3/429?etoc

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes
Li Qian, Linda W. Van Laake, Yu Huang, Siyuan Liu, Michael F. Wendland, and Deepak Srivastava
http://jem.rupress.org/cgi/content/abstract/208/3/549?etoc

Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore
Qun Chen, Edward J. Lesnefsky
http://dx.doi.org/10.1016/j.febslet.2011.02.029

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